Integrity Research - TB-500/BPC-157

Integrity Research BPC-157 / TB-500 — Dual Peptide (Wolverine Stack)

Integrity Research BPC-157 / TB-500 is a dual-peptide research compound combining two of the most studied synthetic peptides in tissue repair science — commonly referred to in investigational contexts as the Wolverine Stack. Each capsule delivers 500 mcg of BPC-157 (Arginate Salt) and 200 mcg of TB-500 (Ac-SDKP), formulated for laboratory research into tissue repair signaling, angiogenesis, cellular migration, and connective tissue integrity.

This product is manufactured exclusively for qualified research and laboratory use. It is not intended for human consumption, medical treatment, or dietary supplementation.

Research Facts

What Is the Wolverine Stack?

The Wolverine Stack is an informal term used in research and investigational communities to describe the combined study of BPC-157 and TB-500 — two peptides with distinct but complementary roles in the tissue repair signaling cascade. The name reflects the regenerative focus of the research: BPC-157 is associated with early-phase local tissue protection and vascular stabilization, while TB-500 is studied for its role in systemic cell migration, actin regulation, and structural remodeling at later repair stages.

In controlled laboratory models, the combination is examined for its multi-phase signaling profile — BPC-157 addressing localized vascular and connective tissue response, and TB-500 driving the broader cellular migration and matrix remodeling that follows. Preclinical data from individual peptide studies suggest their mechanisms operate on complementary timelines, which is the primary rationale for studying them as a paired system rather than independently. The Wolverine Stack is not a medical protocol, an approved therapy, or a dietary supplement — it is a descriptive term used in research and academic contexts.

Compound Overview: BPC-157 & TB-500

BPC-157 — Body Protection Compound (Arginate Salt)

BPC-157 is a synthetic pentadecapeptide derived from a naturally occurring protective sequence in gastric juice. In preclinical research models, it has been studied extensively for its involvement in angiogenesis (new blood vessel formation), fibroblast activity and collagen synthesis, growth factor modulation (including VEGF and EGF pathways), connective tissue signaling in muscle, tendon, and ligament models, gastrointestinal mucosal integrity, and inflammatory cytokine modulation. The Arginate Salt form used in this formulation is a stabilized version of BPC-157 designed for improved compound stability in research applications. A 2025 PMC-published narrative review confirmed BPC-157's preclinical evidence in orthopaedic and sports medicine research, noting improvements in tendon healing and tendon-to-bone integration in animal models.

TB-500 — Thymosin Beta-4 Fragment (Ac-SDKP)

TB-500 is a synthetic analog of Thymosin Beta-4 — a naturally occurring protein involved in cell migration, cytoskeletal reorganization, and connective tissue repair. As the biologically active fragment Ac-SDKP, it is primarily studied for its roles in actin upregulation and cellular mobility, angiogenesis and new blood vessel formation, collagen architecture and extracellular matrix remodeling, reduction of fibrotic scarring in soft tissue models, and systemic recovery signaling across multiple tissue types. Where BPC-157 is associated with localized protective and vascular signaling, TB-500's systemic cell-migration activity makes it a complementary — rather than redundant — addition to the Wolverine Stack research model.

Research Synergy: Why the Combination Is Studied

Published and preclinical literature identify BPC-157 and TB-500 as operating on distinct but sequential pathways in the tissue repair cascade. BPC-157 is associated with early-phase vascular stabilization, microcirculation support, and local tissue protection — preserving the structural environment for repair to begin. TB-500 then supports the migration of regenerative progenitor cells into the damaged zone, reorganizes the cytoskeletal matrix, and drives remodeling of collagen architecture that determines long-term structural recovery. Together, they are studied for multi-tissue research models (muscle, tendon, ligament, nerve), angiogenesis and microcirculation, wound healing and re-epithelialization, ischemia-reperfusion and hypoxic injury, and extracellular matrix and collagen turnover.

Quality & Research Integrity

Integrity Research compounds are manufactured with pharmaceutical-grade materials and HPLC-tested for identity and purity. Batch-to-batch consistency is a primary design objective — supporting reproducible data across independent research experiments. All compounds are produced exclusively for research use and distributed only to qualified research and laboratory purchasers.

Intended Use & Legal Disclaimer

This product is intended exclusively for qualified researchers, laboratories, and institutional research environments. It is not intended for human consumption, self-administration, medical or therapeutic use, dietary supplementation, athletic enhancement, or veterinary application.

FOR RESEARCH PURPOSES ONLY. This product has not been evaluated or approved by the FDA for human consumption, medical use, or dietary supplementation. It is not intended to diagnose, treat, cure, or prevent any disease. By purchasing this product, you acknowledge that you are a qualified professional conducting legitimate research and assume full responsibility for compliance with all applicable laws and regulations in your jurisdiction. Animal Supps is not liable for any misuse of this product, including but not limited to bodily harm, legal consequences, or other damages resulting from improper use. If you do not agree with these terms, do not purchase or use this product.

Related Research Compounds

• Integrity Research BPC-157 / TB-500 Nasal Spray — Wolverine Stack in nasal spray delivery format for alternative research administration models.
• Integrity Research BPC-157 — Single-compound BPC-157 for isolated tissue repair signaling research.
• Integrity Research TB-500 — Single-compound TB-500 for isolated cell migration and remodeling research.